Propagation of Group a Coxsackie Viruses in Tissue Cultures

In contrast with the 6 Group B Coxsackie viruses which readily induce a cytopathic effect (CPE) in tissue cultures, many of the Group A viruses have either failed to alter visibly cells propagated in cultural systems, or have required "adaptation" for such an effect. In the course of studies made during the last two years we have obtained CPE on primate cells cultured in vitro for all except 7 serotypes among the 24 Group A viruses.